B15 Panagamic Acid:
Cell Respiration and Oxidation
Panagamic Acid, also called dimethylglycine, is a water-soluble nutrient which has been used to treat acute and chronic physical traumas. Its primary healing property seems to be its ability to eliminate hypoxia, an insufficient supply of oxygen. It is primarily used in Russia and other European countries, but has been virtually ignored by the United States. "The Russians have studied B15 most intensively and have reported it useful in treating a wide variety of stressful and traumatic situations such as alcoholism and other substance addictions, autism, mental illnesses, minimal forms of brain damage, senility, aging, Alzheimer's Disease, heart disease, diabetes, liver disease and other organ poisoning and acute athletic injuries" (1). Panagamic Acid seems to assist in healing through oxygenating the blood and improving the circulation, thereby more efficiently carrying vital nutrients to the whole body. It brings a better supply of oxygen particularly to the cardiac and other muscles (2).
Although most sources state that little is known about panagamic acid, there have been quite a few scientific studies on the substance. Here are a couple of them:
Graber CD, et al; Immunomodulating properties of dimethylglycine in humans. (J Infect Dis, 1981 Jan, Abstract available) [MEDLINE]
This study showed a four-fold increase in antibody response in those taking dimethylglycine (panagamic acid). This study suggests that it is a powerful immune system stimulant.
Hostetler KY, et al; Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine. (Antimicrob Agents Chemother, 1992 Sep, Abstract available) [MEDLINE]
This study found
that dimethylglycine greatly inhanced the body's ability to inhibit
of HIV type one.
According to Dr. Bernard Rimland, "In 1965, two Russian investigators, M. G. Blumena and T. L. Belyakova, published a report showing considerable improvement in the speech of 12 of a group of 15 mentally handicapped children who had not been able to use speech to communicate. The children had been treated with a substance variously known as calcium pangamate, or pangamic acid, or “vitamin B15.” In addition to enriched vocabulary, the children began to use simple sentences, their general mental state improved, and there was better concentration and interest in toys and games. Subsequent research has shown the essential factor in calcium pangamate to be DMG" (3). It has also been used successfully to assist individuals with autism.
Although it was named Vitamin B15 in 1951 by Dr. Ernest Krebs who discovered it, panagamic acid really cannot be called a vitamin because it has not been demonstrated that a deficiency of it causes disease. However, I believe this is because they do not count free radical damage as a disease, even though free radical damage itself is known to contribute to many disease processes. However, panagamic acid can be sold as long as it is not called a vitamin or a drug. It is marketed as food because it is found in apricot kernels, rice bran, rice polish, whole-grain cereals, brewer's yeast, steer blood, horse liver (2), pumpkin, and sunflower seeds (3).
An article was published in the Journal of Laboratory and Clinical Medicine (1990, 481-486). It described panagamic acid as “natural, simple compound with no known undesirable side effects.” In Russian studies, 50mg were administered twice daily for 20 to 30 days to those with acute injuries. They improved, and with no noticeable side effects. Researchers treating autism have given 50-100mg three times a day with no reported side effects (1).
Ailments which may benefit from Panagamic Acid:
Cirrhosis of liver
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(1) Morris, Ritchi. (2000). Healing From The Inside Out - Part II-A - Acute Injuries. AFPA, Available Online: [http://www.afpafitness.com/HealingPartII.htm].
(2) Dunne, Lavon J. (1990). Nutrition Almanac. New York: McGraw-Hill, p. 34.
Bernard. (1999). Dimethylglycine (DMG), a nontoxic
and autism. San Diego, CA: Autism Research
Available Online: [http://www.bulkmsm.com/DMG/web2.htm].